tamoxifen side effects

The action of proteolytic enzyme preparation derived from the pancreas of cattle. Hydrolysis of proteins and peptones to form relatively low molecular weight peptides, cleaves bonds formed by the remains of aromatic amino acids (tyrosine, tryptophan, phenylalanine, methionine).
In clinical practice, the use of chymotrypsin is based on the specific features of break down necrotic tissue and fibrinous formation dilute viscous secrets and exudates, and when administered intramuscularly to provide anti-inflammatory effect.

Indications for use.
Suppurative disease of the tamoxifen side effects respiratory system (tracheitis, bronchitis, bronchiectasis, pneumonia, lung abscess, atelectasis, pleural effusion, asthma).
In the treatment of burns, pressure ulcers, festering wounds, thrombophlebitis.
In ophthalmology – with fresh extensive thrombosis of the central vein retina, acute obstruction of the central retinal artery, vitreous opacities traumatic and inflammatory origin, cataract extraction.
In otolaryngology – purulent sinusitis, subacute laryngo-tracheitis, after tracheostomy to facilitate removal of the thick viscous exudate, acute, subacute, suppurative, chronic otitis media and evstahiitah viscous exudate.

Contraindications
: Hypersensitivity to chymotrypsin, cancer, pulmonary tuberculosis (open form), chronic heart failure II -. III degree dystrophy and cirrhosis, viral hepatitis, pancreatitis, hemorrhagic diathesis, emphysema, respiratory failure
can not enter into the bleeding cavity, apply ulcerated on the surface of malignant tumors in order to avoid the spread of malignancy.

Be wary.
Empyema of tubercular etiology (absorption of exudate may in some cases contribute to the development of bronchopleural fistula).

Pregnancy and lactation
Data on the use of the drug during pregnancy and lactation is not.

Dosing and Administration.
For intramuscular dissolve immediately before use 0.005 g in 1 to 2 mL of sterile 0.9% sodium chloride solution or 0.5-2% procaine solution. Treatments -. 6-15 injections
In respiratory diseases, drug use intramuscularly in doses of 5-10 mg per day for 10-12 days, can be combined with aerosol chymotrypsin in 5% aqueous solution in an amount 3-4ml. After 7-10 days of treatment may be repeated.
In the treatment of burns and bedsores chymotrypsin at a dose of 20 mg was dissolved in 20 ml of 0.25% solution of procaine and a few thin needle pricks is injected under the scab. In purulent wound surfaces applied 8 hours, sterile wipes, moistened with a solution of 0.025-0.05 g chymotrypsin in 10-50 ml of 0.25% solution of procaine. For the treatment of purulent wounds intramuscular injection combined with local treatment of the wound swab dipped 5% aqueous solution of chymotrypsin.
When thrombophlebitis drug is given intramuscularly at 5-10 mg daily for 7-10 days.
When extraction chymotrypsin cataract in a dilution of 1: 5000 is introduced in posterior chamber of the eye, followed by washing the anterior chamber of 0.9% sodium chloride solution after 4 minutes after administration.
In the treatment of central retinal vein thrombosis, acute obstruction of central artery of retina chymotrypsin subconjunctival administered 0.2 ml of a 5% solution prepared by 1 % solution of procaine, 1-2 times a week.
When the drug is administered in sinusitis corresponding cavity in an amount of 5-10 mg in 3-5 ml of 0.9% sodium chloride and after puncture cavity tamoxifen side effects lavage.
When otitis buried in the ear to 0, 5-1 ml of 0.1% solution of chymotrypsin of 0.9% sodium chloride solution. At the micro-operations on the ear to soften fibrinous formations in the middle ear during surgery injected into the cavity of 0.1% chymotrypsin solution. Simultaneously chymotrypsin should be administered intramuscularly 2.5-5 mg 1-2 times a day. The drug is diluted in 1-2 mL of 0.25-0.5% solution of novocaine or 0.9% sodium chloride solution.

Side effect
May cause allergic reactions, fever up to subfebrialnoy, tachycardia
After inhalation: occasionally observed irritation of the mucous membranes of the upper airways, hoarseness.
When tamoxifen side effects subconjunctival administration may result in irritation and swelling of the conjunctiva; in such cases it is advisable to reduce the concentration of the solution.
After intramuscular administration may be soreness and redness at the injection site.