You can not assign during transport drivers and others persons, professions that require high concentration and speed of psychomotor reactions. During treatment it is necessary to monitor blood pressure, pulse, regularly monitor liver function, kidney and blood. Patients should not be exposed to tamoxifin radiation, because the drug can cause photosensitivity. During treatment should avoid the use of ethanol.
Interaction : With simultaneous use of chlorpromazine with other drugs, have a depressing effect on the central nervous system (funds for general anesthesia, opioids, ethanol (alcohol) and containing its drugs, barbiturates, tranquilizers, and others.) May increase depression and respiratory depression;
undesirably prolonged combination with analgesics and antipyretics – may develop hyperthermia;
tricyclic antidepressants, maprotiline, or tamoxifin inhibitors – increase the risk of neuroleptic malignant syndrome;
with anticonvulsants – may decrease the seizure threshold,
with preparations for the treatment of hyperthyroidism – increased risk of agranulocytosis;
other drugs cause extrapyramidal reactions – may increase the frequency and severity of extrapyramidal disorders; with antihypertensive drugs – possible orthostatic hypotension
with ephedrine – may weaken the vasoconstrictor effect of ephedrine. When treating chlorpromazine avoid administration of epinephrine (adrenaline), since distortion may effect epinephrine, which can lead to a drop in blood pressure. Antiparkinsonian effect of levodopa tamoxifin is reduced due to the blocking of dopamine receptors. Aminazin can suppress the effect of amphetamines, clonidine, guanethidine. Aminazin enhances anticholinergic effects of other drugs, and the antipsychotic effect of neuroleptics may be reduced. With simultaneous use of chlorpromazine with a related chemical structure prochlorperazine may come a long unconsciousness. Antacids, antiparkinsonian drugs, and lithium salts may reduce the absorption of chlorpromazine, besides combination with lithium therapy increases the risk of extrapyramidal complications.
Chlorpromazine may mask some of the manifestations tamoxifin of ototoxicity (tinnitus, vertigo) of drugs that have ototoxic effects (eg. Antibiotics with ototoxic effect) . Other hepatotoxic drugs increase the risk of hepatotoxicity.