In the case of co-administration of these two drugs is recommended to carry out an appropriate frequency determination of prothrombin time until reaching the stable figures of this indicator. Cholestyramine and colestipol reduce bioavailability (lovastatin may use 2-4 hr. After what is tamoxifenadministration of these drugs, while noting additive effect).
Treatment must be accompanied by an appropriate diet .
Therapy drug can cause increased activity of “liver” enzymes. This increase is usually small and clinically insignificant. However, it is recommended to monitor the levels of the enzymes before treatment and during treatment at regular intervals (for one year, then at least one fold at 6 months).
With increasing to three times the upper limit rate of drug treatment should be discontinued.
treatment of drug should be discontinued in the event of a persistent increase of the activity of creatine phosphokinase what is tamoxifen.
This should be considered in the differential diagnosis of chest pain.
Therapy can lead to myopathy, and as a consequence, to rhabdomyolysis and renal failure. The risk of this disease increases in patients receiving both, one or more of the what is tamoxifen following drugs: fibrates (gemfibrozil, fenofibrate), cyclosporine, nefazodone, macrolides (erythromycin, clarithromycin), antifungal agents of “azole” group (ketoconazole, itraconazole) and inhibitors proteases (ritonavir).The risk of myopathy is also increased in patients with severe renal insufficiency. Patients should promptly inform your doctor in case of unexplained pain in the muscles, especially if accompanied by malaise or fever.
Caution should be exercised when using in patients who consume excessive amounts of alcohol, and in patients with liver disease in history.
In the period treatment, women of childbearing age should use reliable contraception.
Less effective in patients with rare homozygous familial hypercholesterolemia , possibly because these patients are no functioning receptors. Apparently, in these patients can increase faster Activity “liver” transaminases.
Lovastatin has only a modest effect in reducing triglycerides and not shown in the cases where the primary pathology is hypertriglyceridemia what is tamoxifen
.Effects on ability to drive and other complex mechanisms: There was no any effect on the ability to drive a car or work with technical devices.